It sounds like you are doing everything that you can to give your mother's cat a wonderful home. If your vet ruled out urinary tract infections (very common in cats), then you can try keeping the litter box very, very clean. I have 2 fussy female cats who will not use the box unless it is pristine (yes, I'm their human servant -- lol !). I know that cats dislike change, but the opposite just may work. Why not try a new, different style (i.e. open box) litter box? I once had a cat who stopped using his box. I always kept it clean. I finally decided to try a new box (it was also bigger -- which I thought would make it easier for him) and it worked! Of course, I would keep the old box, just in case! Good luck!
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